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目的:探讨血管内皮生长因子(VEGF)与宫颈癌临床病理因素的关系及新辅助化疗(NACT)对VEGF的表达影响。方法:采用SP免疫组化法检测60例Ⅰb2和Ⅱa期宫颈癌组织中VEGF表达,以阳性表达率作为评价指标,并对NACT前后的VEGF表达进行比较,评价NACT后的近期临床疗效。结果:NACT前,病灶直径≥4 cm的VEGF阳性表达为91.9%,显著高于病灶直径<4 cm(P<0.05);低分化组织中VEGF阳性表达率为87.8%,显著高于中高分化(P<0.05);Ⅰb2期的VEGF阳性表达为93.8%,显著高于Ⅱa期(P<0.05)。宫颈癌组织中VEGF阳性表达率与NACT前比较显著下降(P<0.05)。NACT后,完全缓解6例,部分缓解42例,稳定12例,无进展病例,有效率为80.0%,疾病控制率为100.0%。结论:VEGF在宫颈癌组织中的表达与局部病灶大小、肿瘤分化和临床分期有关,宫颈癌组织中VEGF的表达可能作为NACT疗效的预测指标。
Objective: To investigate the relationship between vascular endothelial growth factor (VEGF) and clinicopathological factors and the effect of neoadjuvant chemotherapy (NACT) on the expression of VEGF. Methods: The expression of VEGF in 60 cases of stage Ⅰ 2b and Ⅱ a cervical carcinoma was detected by SP immunohistochemical method. The positive expression rate was used as the evaluation index. The VEGF expression before and after NACT was compared to evaluate the clinical effect after NACT. Results: Before NACT, the positive expression of VEGF with a diameter of 4 cm or more was 91.9%, which was significantly higher than that of lesion <4 cm (P <0.05). The positive expression rate of VEGF in poorly differentiated tissue was 87.8% P <0.05). The positive expression of VEGF in stage Ⅰb2 was 93.8%, which was significantly higher than that in stage Ⅱa (P <0.05). The positive rate of VEGF in cervical cancer tissues was significantly lower than that before NACT (P <0.05). After NACT, complete remission in 6 cases, partial remission in 42 cases, stable in 12 cases, no progress cases, the effective rate was 80.0%, the disease control rate was 100.0%. Conclusion: The expression of VEGF in cervical cancer is related to the size of local lesion, tumor differentiation and clinical stage. The expression of VEGF in cervical cancer may be used as a predictor of the efficacy of NACT.