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本文测定了48例脑梗塞、20例脑动脉硬化患者及30例正常人的红细胞(RBC)膜胆固醇(CHO)、磷脂(PL)和脂质过氧化物(LPO)。并根据梗塞灶的大小、病程的长短将病人分为2组。发现脑梗塞病人RBC膜CHO、LPO、CHO/PL比值明显高于正常组和脑动脉硬化组;膜PL低于正常组与脑动脉硬化组;上述结果在恢复期病人与脑动脉硬化组间无显著性差异;脑梗塞的大小与膜CHO、PL、CHO/PL、LPO有显著相关性。本实验结果提示红细胞膜脂质成份与脂质过氧化改变和脑梗塞密切相关,且主要在急性期明显,梗塞面积越大,改变越明显。
In this study, 48 cases of cerebral infarction, 20 cases of cerebral arteriosclerosis and 30 cases of normal people were detected RBC cholesterol (CHO), phospholipid (PL) and lipid peroxides (LPO). And according to the size of infarction, duration of the disease will be divided into two groups. It was found that the RBC membrane CHO, LPO, CHO / PL ratio of cerebral infarction patients was significantly higher than that of normal group and cerebral arteriosclerosis group; membrane PL was lower than that of normal group and cerebral arteriosclerosis group. These results showed no difference between convalescent patients and cerebral arteriosclerosis group Significant differences; infarct size and membrane CHO, PL, CHO / PL, LPO significant correlation. The experimental results suggest that lipid composition of erythrocyte membrane and lipid peroxidation changes and cerebral infarction are closely related, and mainly in the acute phase, the larger the infarct size, the more obvious changes.