论述了针对吐－哈（吐鲁西－哈密盆地）油田鄯善、丘陵、温吉桑（温西）、米登等四个构造并下复杂的具体情况所开展的岩石矿物组份和理化性能分析研究工作，进行了钻井液配套研究。最后研制出适合吐－哈油田的淡水高坂土钻井液、两性离子聚合物钻井液及新型聚磺钻井液体系，取得了显著效果，开创了安全、优质、快速、低耗钻井的新局面。 In this paper, the rock mineral composition and physical and chemical properties of the four structures in the Tu-Ha (Turquoise-Hami Basin) oilfields, such as Shanshan, Hilly, Wenge Sang Analysis and research work, carried out drilling fluid matching research. In the end, freshwater Kosaka soil drilling fluid, zwitterionic polymer drilling fluid and new polysulfonic drilling fluid system suitable for Tuoboha Oilfield have been developed, which has achieved remarkable results and created a new situation of safe, high quality, fast and low consumption drilling.