哺乳动物雷帕霉素靶蛋白(mTOR)是一种非典型的丝氨酸/苏氨酸蛋白激酶,其行使生理功能主要通过两种不同的蛋白质复合体mTORC1和mTORC2. mTORC1调节蛋白质的合成、细胞的生长增殖,而mTORC2调节细胞的存活.研究表明,mTOR在心脏发育和重构中发挥关键调节作用.寻找心脏特异性mTORC1的抑制剂,而不损害其生理功能,可能为心血管疾病治疗提供新思路.“,”The protein kinase mammalian or mechanistic target of rapamycin (mTOR)is an atypical serine-threonine kinase that exerts its main cellular functions by 2 different multiprotein complexes , mTOR complex 1 ( mTORC1) and mTOR complex 2 ( mTORC2 ).The mTORC1 regulates protein synthesis ,cell growth and proliferation ,autophagy and cell metabolism ,whereas mTORC2 regulates cell survival. Studies have shown that the mTOR pathway plays a key regulatory function in cardiac development and reconstruction .Looking for specific mTORC1 inhibitor,without compromising physiological function of mTOR ,may provide new ideas for the treatment of cardiovascular disease.