Objective: To study the effect of Yangqixue Qufengshi Recipe (养气血祛风湿方, YQXQFS) on rheumatoid arthritis (RA) model mice under different genetic backgrounds. Methods: Collagen Induced Arthritis (CIA) were established on HLA-DR4 transgenic (TG) mice and non-transgenic (NTG) mice, which partly were raised with YQXQFS, and the onset day of CIA, the level of type Ⅱcollagen (CⅡ)-reactive antibodies and the pathological scores of CIA were assessed. Results: Under HLA-DR4 TG background (compared with NTG mice), the earlier onset day of CIA (11.22±3.35 days vs 16.56±4.75 days, P<0.05) and higher level of CⅡ-reactive antibodies (0.2274±0.1390 μg/ml vs 0.1101±0.0560 μg/ml, P<0.05) were observed, but the pathological scores of CIA remained unchange. YQXQFS could not influence the onset day of CIA and the level of CⅡ-reactive antibodies, but had a certain effect on the total pathological scores (6.56±3.43 scores vs 11.11±5.64 scores) and bone erosion (0.22±0.44 scores vs 1.67±1.50 scores) of CIA on NTG mice (P<0.05), NTG YQXQFS group compared with NTG experimental group. Conclusion: YQXQFS had a certain effect on RA model, but had no significant effect on HLA-DR4 related CIA. Objective: To study the effect of Yangqixue Qufengshi Recipe (YQXQFS) on rheumatoid arthritis (RA) model mice under different genetic backgrounds. Methods: Collagen Induced Arthritis (CIA) were established on HLA-DR4 transgenic (TG ) mice and non-transgenic (NTG) mice, which are raised with YQXQFS, and the onset day of CIA, the level of type IIcollagen (CII)-reactive antibodies and the pathological scores of CIA were assessed. Results: Under HLA- DR4 TG background (compared with NTG mice), the earlier onset day of CIA (11.22±3.35 days vs 16.56±4.75 days, P<0.05) and higher level of CII-reactive antibodies (0.2274±0.1390 ​​μg/ml vs 0.1101±0.0560 Μg/ml, P<0.05) were observed, but the pathological scores of CIA remained unchange. YQXQFS could not influence the onset day of CIA and the level of CII-reactive antibodies, but had a certain effect on the total pathological scores (6.56 ±3.43 scores vs 11.11±5.64 scores) and bone erosion (0.22±0.44 scores Vs 1.67±1.50 scores of CIA on NTG mice (P<0.05), NTG YQXQFS group compared with NTG experimental group. Conclusion: YQXQFS had a certain effect on RA model, but had no significant effect on HLA-DR4 related CIA.