论文部分内容阅读
电离辐射对人类的遗传效应是当前放射生物学的重要研究课题之一,一直受到人们的关注。近年来一些学者通过对动物(主要是小鼠)出生前的宫内检胚研究显性致死突变的诱发率,指出同一放射剂量诱发的不同发育阶段生殖细胞的显性致死突变率存在显著差异,但这些研究大多是以χ射线急性照射进行的,后来虽有以γ射线照射诱发显性致死突变的研究,但多数只对雄性动物进行照射。为给评价人类辐射遗传的危害提供参考资料,我们认为对一次急性照射雄性小鼠与长期小剂量慢性照射雌、雄性小鼠诱发的显性致死突变作比较研究是有一定意义的。
The genetic effect of ionizing radiation on human beings is one of the important research topics in current radiobiology and has received people’s attention. In recent years, some scholars have studied the prevalence of dominant fatal mutations in animals before birth (mainly mice), and pointed out that there is a significant difference in the dominant lethal mutation rate of germ cells at different developmental stages induced by the same radiation dose. However, most of these studies were conducted with acute irradiation of gamma rays. Although there were studies on dominance of lethal mutations induced by gamma irradiation, most of them were only irradiated to male animals. In order to provide reference data for assessing human radiation genetic hazards, we believe that a comparative study of a single dominant acute lethal male-male mouse induced by acute irradiation with a long-term low-dose mice is of some significance.