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目的:探讨动态监测血清降钙素原水平在优化全身性感染患者抗菌治疗策略中的价值。方法:选择2015年12月至2016年12月期间EICU收治的46例全身性感染患者患者作为研究对象,并随机分为观察组和对照组,对照组根据《抗菌药物临床应用指导原则(2015年版)》使用抗生素,观察组监测血清PCT水平,PCT≥0.25ng/mL时使用抗生素,当PCT<0.25ng/mL停用抗生素。结果:观察组的白细胞计数和C反应蛋白水平优于对照组,有统计学意义(P<0.05);两组的住ICU时间和复发率比较,有统计学意义(P<0.05)。结论:动态监测血清PCT水平更有助于合理使用抗生素,降低复发率和病死率,值得在临床上推广。
Objective: To investigate the value of dynamic monitoring serum procalcitonin in the strategy of antimicrobial therapy to optimize systemic infection. Methods: Forty-six patients with systemic infection admitted to EICU from December 2015 to December 2016 were selected as study subjects and randomly divided into observation group and control group. According to the Guidelines for Clinical Application of Antibacterial Drugs (2015 Edition) ) "Antibiotics were used in the observation group to monitor serum PCT levels. Antibiotics were used at PCT ≥ 0.25 ng / mL and antibiotics were discontinued at PCT <0.25 ng / mL. Results: The white blood cell count and C-reactive protein level in the observation group were better than those in the control group (P <0.05). The ICU time and recurrence rate in the two groups were statistically significant (P <0.05). Conclusion: The dynamic monitoring of serum PCT levels is more helpful for the rational use of antibiotics, reducing the recurrence rate and mortality, which is worth to be popularized clinically.