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本文以尿激酶治疗63例糖尿病性周围神经病变患者,与28例糖尿病周围神经病变患者静滴生理盐水为对照进行疗效对比观察。结果表明:总有效率尿激酶组为92.1%,对照组为28.6%(P<0.005)。两组患者治疗后生化指标的变化比较:胆因醇(Ch)变化无差异性(P>0.05),而甘油三酯(TG)、低密度脂蛋白胆固醇(LDL—Ch)、高密度脂蛋白胆固醇(HDL—Ch)与空腹血糖(FBG)的变化均差异显著(P<0.01,P<0.05,P<0.05,P<0.01)。在治疗过程中全部病例均未见有出血和过敏现象。本组资料表明:尿激酶不仅对改善糖尿病性周围神经病变、降低血脂和血糖有确切的疗效,而且未见副作用,是值得临床上继续探索和应用的一种方法。
In this paper, urokinase treatment of 63 patients with diabetic peripheral neuropathy, and 28 cases of diabetic peripheral neuropathy patients with intravenous saline as a control for the efficacy of controlled trials. The results showed that the total effective urokinase group was 92.1% and the control group was 28.6% (P <0.005). There was no significant difference in biochemical parameters between the two groups after treatment (P> 0.05), while triglyceride (TG), low density lipoprotein cholesterol (LDL-Ch), high density lipoprotein Cholesterol (HDL-Ch) and fasting blood glucose (FBG) were significantly different (P <0.01, P <0.05, P <0.05, P <0.01). In the course of treatment, no bleeding and allergy were observed in all cases. This group of data shows that: urokinase not only to improve the diabetic peripheral neuropathy, reduce blood lipids and blood glucose have the exact effect, but no side effects, it is worth to continue to explore and application of a method.