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目的 探讨Ⅱ型糖尿病患者胃液排空功能，同时观察西沙比利对糖尿病胃轻瘫的疗效。方法 应用超声检查对22例正常组及20例糖尿病患者的胃液半排空时间进行比较，并用西沙比利（10 mg tid）治疗其中11名有胃轻瘫的病人，4周后复查对照。结果 正常组胃液半排空间为（t1/2）（14.80±4.35）min，Ⅱ型糖尿病组的胃半排空时间为（28.00±8.94）min，二者之间有显著的差异。口服西沙比利后11名患者的胃半排空时间由（33.64±5.05）min减至（20.91±5.39）min。结论 糖尿病患者胃排空有明显的障碍，西沙比利可改善糖尿病胃轻瘫，本实验为糖尿病人临床应用西沙比利治疗提供了理论依据。
Objective To investigate the gastric emptying function in patients with type Ⅱ diabetes mellitus and observe the effect of cisapride on diabetic gastroparesis. Methods The gastric emptying time of gastric juice was compared between 22 normal subjects and 20 diabetic patients by ultrasound. 11 patients with gastroparesis were treated with cisapride (10 mg tid), and the control was reviewed after 4 weeks. Results The half-space of gastric juice in normal group was (t1 / 2) (14.80 ± 4.35) min and the gastric half-emptying time in type Ⅱ diabetes group was (28.00 ± 8.94) min, with significant difference between the two groups. The gastric emptying time in 11 patients after oral cisapride decreased from (33.64 ± 5.05) min to (20.91 ± 5.39) min. Conclusions There is obvious obstruction of gastric emptying in diabetic patients and cisapride can improve diabetic gastroparesis. This study provides a theoretical basis for the clinical application of cisapride in diabetic patients.