论文部分内容阅读
从1928年Fleming发现青霉素,1945年Brotzu发现头孢菌素,特别是从1942年青霉素G应用于临床,1962年又制造成功头孢菌素Ⅰ以来,β-内酰胺抗生素在细菌性感染症的治疗中一直起重要作用。半合成青霉素和头孢菌素的发展,加上近年来发现的非典型β-内酰胺抗生素,已经构成了一个庞大的β-内酰胺抗生素族。β-内酰胺抗生素在近年来的发展及其在医药工业、临床应用上的地位已有许多专著和综述。众所周知,从发现青霉素和头孢菌素到现在,β-内酰胺
Penicillin was found in Fleming in 1928, cephalosporin in Brotzu in 1945, penicillin G in clinical application in 1942, and successful cephalosporin I in 1962. β-lactam antibiotics have been used in the treatment of bacterial infections Has always played an important role. The development of semisynthetic penicillins and cephalosporins, combined with the atypical β-lactam antibiotics found in recent years, has constituted a large family of β-lactam antibiotics. In recent years, the development of β-lactam antibiotics and its position in the pharmaceutical industry, clinical applications, there are many monographs and reviews. It is well known that β-lactams have been found since the discovery of penicillins and cephalosporins