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吗替麦考酚酯(mycophenolate mofetil,MMF)在体内脱酯化后形成具有免疫抑制活性的吗替麦考酚酸(mycophenolicacid,MPA)。MPA是次黄嘌呤核苷酸脱氢酶(I MPDH)的可逆性、非竞争性抑制剂[1],抑制嘌呤的生物合成。MMF不仅能够有效地抗急性和慢性排异反应,而且没有肾毒性。与环孢霉
Mycophenolate mofetil (MMF) is deesterified in vivo to form immunosuppressive mycophenolic acid (MPA). MPA is a reversible, non-competitive inhibitor of inosine monophosphate dehydrogenase (I MPDH) [1] that inhibits purine biosynthesis. Not only can MMF be effective against acute and chronic rejection but also have no renal toxicity. With cyclosporium