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目的观察雷贝拉唑、阿莫西林克拉维酸、替硝唑三联疗法对幽门螺杆菌的根除和消化性溃疡的治疗作用。方法82例Hp阳性的消化性溃疡患者给予雷贝拉唑10 mg、替硝唑500 mg,2次/天,阿莫西林克拉维酸312.5 mg,3次/d,连服7 d,观察腹痛缓解率、溃疡愈合率、Hp根除率和不良反应的发生率。结果临床腹痛缓解率为97.6%,治疗结束后Hp根除率为92.6%,溃疡愈合率为93.9%,不良反应的发生率为6.1%。结论雷贝拉唑、阿莫西林克拉维酸、替硝唑三联疗法是一种治疗幽门螺杆菌感染和消化性溃疡的安全、有效、快速的方法。
Objective To observe the therapeutic effect of rabeprazole, amoxicillin clavulanic acid and tinidazole triple therapy on the eradication and peptic ulcer of Helicobacter pylori. Methods Eighty-two patients with Hp-positive peptic ulcer were given rabeprazole 10 mg, tinidazole 500 mg, twice daily, and amoxicillin-clavulanate 312.5 mg three times daily for 7 days. The abdominal pain Remission rate, ulcer healing rate, Hp eradication rate and the incidence of adverse reactions. Results The remission rate of clinical abdominal pain was 97.6%. After the treatment, the eradication rate of Hp was 92.6%, the healing rate of ulcer was 93.9% and the incidence of adverse reactions was 6.1%. Conclusion Rabeprazole, amoxicillin and clavulanic acid, tinidazole triple therapy is a safe, effective and rapid method for the treatment of Helicobacter pylori infection and peptic ulcer.