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目的对使用注射用甲泼尼龙琥珀酸钠(甲强龙)治疗急性肺损伤后肺纤维化患者并实施护理干预后的效果进行探究。方法 120例急性肺损伤后肺纤维化患者,随机分为对照组与观察组,每组60例。对照组采用常规护理外加口服醋酸泼尼松片,观察组采用常规护理外加注射甲强龙。对两组的疗效进行比较。结果治疗前两组患者肺活量(VC)、CO弥散量(DLCO)比较差异均无统计学意义(P>0.05);治疗后观察组VC(2.13±0.19)L、DLCO(3.79±0.85)mmol/(min·k Pa)均高于对照组的(1.98±0.53)L、(3.49±0.27)mmol/(min·k Pa),差异均具有统计学意义(P<0.05)。结论使用甲强龙治疗急性肺损伤后导致的肺纤维化,对控制纤维化和改善肺功能具有良好的治疗效果,配合合适的护理方法 ,效果极好,具有临床意义。
Objective To investigate the effect of using methylprednisolone sodium succinate (methylprednisolone) for the treatment of patients with pulmonary fibrosis after acute lung injury and nursing intervention. Methods 120 patients with pulmonary fibrosis after acute lung injury were randomly divided into control group and observation group, 60 cases in each group. The control group with conventional nursing plus oral prednisone acetate tablets, the observation group using conventional nursing plus injection of methylprednisolone. The efficacy of the two groups were compared. Results Before treatment, there was no significant difference in the vital capacity (VC) and the diffusing capacity of CO (DLCO) between the two groups (P> 0.05); after the treatment, the VC in the observation group was 2.13 ± 0.19 L, (min · kPa) were significantly higher than that of the control group (1.98 ± 0.53) L and (3.49 ± 0.27) mmol / (min · kPa), respectively, with statistical significance (P <0.05). Conclusions The use of methylprednisolone in the treatment of pulmonary fibrosis caused by acute lung injury has a good therapeutic effect on the control of fibrosis and pulmonary function. It is of great clinical significance to cooperate with appropriate nursing methods.