论文部分内容阅读
作者对1例用重组α_2干扰素(IFN-α_2)长期治疗的毛细胞白血病(HCL)患者进行了体外免疫功能研究。患者男性53岁。用重组IFN-α_2进行治疗,每周用药3次,每次2×10~6U/m~2。在治疗的9个月期间和停药后3个月中发现各项指标有以下变化;(1)治疗的第1周外周血细胞数减少,第3周血小板计数回升至正常值,9～10周血红蛋白、中性粒细胞及单核细胞均恢复正常,而淋巴细胞数则在停药后才恢复正常。(2)在治疗期间,B淋巴细胞分泌免疫球蛋白呈逐渐降低趋势,但仍维持在正常范围。(3)外周血单个核细胞(PBMC)与正
The authors conducted an in vitro immunosuppression study of 1 human hair cell leukemia (HCL) patient treated with recombinant interferon alpha (IFN-α 2). The patient is 53 years old. With recombinant IFN-α_2 treatment, medication 3 times a week, each 2 × 10 ~ 6U / m ~ 2. During the 9 months of treatment and 3 months after discontinuation, the following changes were found in each index: (1) the number of peripheral blood cells in the first week of treatment decreased, the platelet count rose back to the normal value in the third week, 9 to 10 weeks Hemoglobin, neutrophils and monocytes returned to normal, while the number of lymphocytes returned to normal after stopping. (2) during the treatment, B lymphocytes secretory immunoglobulin gradually decreased, but still maintained in the normal range. (3) peripheral blood mononuclear cells (PBMC) and positive