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目的 :探讨原发性肾病综合征 (PNS)患者体内氧化损伤状态和抗氧化系统的改变。方法 :测定了 38例肾病综合征患者的血清丙二醛 (MDA)、谷胱甘肽过氧化物酶 (GSH -PX)及血清和红细胞超氧化物歧化酶(SOD)的含量 ,并与正常对照组进行了比较。结果 :38例PNS患者血清丙二醛水平明显高于正常对照组 ,有显著性差异 (P <0 .0 1) ;GSH -PX、血清SOD ,红细胞SOD及SOD/MDA均明显低于正常对照组 ,有显著性差异 (P <0 .0 1)。结论 :脂质过氧化物参与了肾病综合征的致病 ,以及肾病综合征患者抗氧化能力下降导致了肾病综合征患者的发病。
Objective: To investigate the changes of oxidative damage and antioxidant system in patients with primary nephrotic syndrome (PNS). Methods: Serum levels of malondialdehyde (MDA), glutathione peroxidase (GSH-PX) and serum and erythrocyte superoxide dismutase (SOD) in 38 patients with nephrotic syndrome were measured and compared with normal Control groups were compared. Results: Serum malondialdehyde levels in 38 PNS patients were significantly higher than those in normal controls (P <0.01); GSH-PX, serum SOD, erythrocyte SOD and SOD / MDA were significantly lower than those in normal controls Group, there was significant difference (P <0.01). CONCLUSIONS: Lipid peroxides are involved in the pathogenesis of nephrotic syndrome and in patients with nephrotic syndrome due to decreased antioxidant capacity leading to the onset of nephrotic syndrome.