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目的了解冠心病患者的心率变异性(heart rate variability,HRV)的改变,探讨冠心病自主神经变化的临床意义。方法选择冠心病患者150例作为冠心病组,无冠心病者150例作为正常对照组,测定心电图的时域和频域指标,并进行比较分析。结果与对照组比较,冠心病组HRV时域指标SDNN、SDANN、RMSSD、PNN50均显著降低(P<0.01),频域指标HF有明显降低(P<0.05),两组差异有统计学意义。结论冠心病患者存在心脏自主神经功能紊乱现象,以交感神经活动占优势。
Objective To investigate the changes of heart rate variability (HRV) in patients with coronary heart disease and to explore the clinical significance of autonomic nerve changes in patients with coronary heart disease. Methods 150 patients with coronary heart disease were selected as coronary heart disease group and 150 patients without coronary heart disease as control group. The time and frequency indexes of electrocardiogram were measured and compared. Results Compared with the control group, the HRV time domain indexes of SDNN, SDANN, RMSSD and PNN50 in coronary heart disease group were significantly decreased (P <0.01) and the frequency domain index HF was significantly decreased (P <0.05). There was significant difference between the two groups. Conclusion Coronary heart disease patients have cardiac autonomic dysfunction phenomenon, with the sympathetic activity predominance.