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一九七五年Miller等强调了血浆高密度胎蛋白(HDL)胆固醇浓度和冠心病的发生率呈反比关系。此事实以前曾被提及,但大都被忽视了。此后,几个国家所做的前瞻性研究均已证实了这种关系,发现它独立于其它多种危险因素。虽对HDL在脂质运输中的作用有较多了解,但其对抗动脉粥样硬化的发生机理仍不清楚。
In 1975, Miller et al. Emphasized the inverse relationship between plasma high-density cholesterol (HDL) cholesterol and the incidence of coronary heart disease. This fact has been mentioned before, but mostly ignored. Since then, prospective studies in several countries have confirmed this relationship and found that it is independent of many other risk factors. Although the role of HDL in lipid transport more knowledge, but the mechanism of its fight against atherosclerosis is still not clear.