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目的探究乌鲁木齐地区维吾尔族(维族)与汉族前列腺癌患者的骨转移特点。方法分别对75例维族和82例汉族前列腺癌患者采用SPECT进行全身核素骨显像,放射免疫法分析法测定血清骨钙素(BGP)水平,化学发光免疫分析法测血清白介素-6(IL-6)、游离前列腺特异抗原(F-PSA)和血清总前列腺特异抗原(T-PSA)水平及其比值(F/T)。结果骨显像阳性率维族为54.67%(75例),低于汉族76.83%(82例),血清骨钙素和IL-6水平维族均低于汉族,差异均有统计学意义(P<0.05);血清F-PSA和T-PSA水平,两民族间差异无统计学意义(P>0.05),但其比值(F/T)维族明显高于汉族(P<0.05)。结论乌鲁木齐地区维族与汉族前列腺癌患者骨转移不同,汉族患者更容易发生骨转移,且肿瘤代谢指标活跃,累及范围较广,预后差。
Objective To investigate the bone metastasis of Uygur (Uighur) and Han nationality in Urumqi. Methods 75 cases of Uygur and 82 cases of Han nationality prostate cancer were enrolled in this study. Whole body radionuclide bone imaging was performed by SPECT. Serum BGP levels were measured by radioimmunoassay. Serum IL - 6 (IL - 6) was measured by chemiluminescence immunoassay. -6), free prostate specific antigen (F-PSA) and total prostate specific antigen (T-PSA) and its ratio (F / T). Results The positive rate of Uygur in bone imaging was 54.67% (75 cases), which was lower than 76.83% (82 cases) in Han nationality. The Uygur serum of serum osteocalcin and IL-6 were lower than Han nationality (P <0.05) ). There was no significant difference between the two ethnic groups in F-PSA and T-PSA levels (P> 0.05). However, the ratio of F / T Uygur was significantly higher than Han (P <0.05). Conclusions Uygur and Han nationality patients with prostate cancer have different bone metastases in Urumqi region. Patients with Han are more likely to have bone metastases, and the tumor metabolism indicators are active, involving a wide range and poor prognosis.