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目的:探讨异丙酚复合七氟烷麻醉对肝叶切除术患者一氧化氮(NO)/内皮素-1比例的影响.方法:84例肝叶切除术患者随机分为两组,观察组42例患者实施异丙酚复合七氟烷麻醉,对照组42例患者采用咪达唑仑维持麻醉,分别于肝门阻断前、肝门阻断后、术后3d检测两组患者血NO、内皮素-1、肝功能指标(AST、ALT)、炎症因子[白介素-1(IL-1)、白介素-10(IL-10)、肿瘤坏死因子α(TNF-α)]水平变化.结果:肝门阻断前,两组患者上述指标差异无统计学意义(P>0.05);肝门阻断后,两组患者NO、IL-10明显降低,内皮素-1、AST、ALT、IL-1、TNF-α明显升高,且两组差异有统计学意义(P0.05). After hepatic portal occlusion, NO and IL-10 decreased significantly, while endothelin-1, AST,ALT,IL-1 and TNF-α increased significantly in the two groups.The differences between the two groups were statistically signifi-cant (P<0.01). All indices at postoperative 3 d in two groups recovered to the level before hepatic portal occlusion.Conclusion:Propofol combined with sevoflurane anesthesia contributes to adjusting nitric oxide/endothelin-1 ratio in the patients with hepatic lobec-tomy,which can improve liver function and inhibit the release of inflammatory cytokines.