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为探讨肝素治疗微循环中有微血栓，心电图有心肌损害的大鼠的疗效及可能的机理，我们用静脉注射高分子右旋糖酐的方法，复制有微血栓及心电图异常的大鼠模型，用肝素或盐水作对比治疗，结果显示：肝素治疗后，心电图有非常明显改善，提高的ＳＴ段基本恢复，原升高的血粘度，明显降低，肠系膜中红细胞的粘测、聚集明显减轻，微血栓数目明显减少，这可能是心肌缺血，缺氧改善的基础。但对此种“大鼠作心肌细胞膜上 Ｎａ～（＋）－ Ｋ～（＋）－ ＡＴＰ酶活性测定的结果表明，此酶活性有上升趋势，与盐水组相比，酶活性无明显差异，提示心肌细胞膜上Ｎａ～（＋）泵的恢复较心电图改善，微血栓减少慢，强调在用肝素治疗后，心电图改善之初，还需加强心肌保护，促使心肌细胞膜上纳泵的早期恢复治疗．
In order to investigate the therapeutic effect and possible mechanism of heparin in treating microthrombus in micro-circulation and myocardial damage in electrocardiogram, we used intravenous injection of dextran to replicate microthrombus and electrocardiogram abnormal rat model, Saline treatment, the results showed that: after heparin treatment, electrocardiogram has been significantly improved, improved ST segment recovery, the original increased blood viscosity, decreased significantly, mesentery in the red blood cells viscous test, agglomeration significantly reduced, the number of micro-thrombus was significant Reduce, this may be the basis of myocardial ischemia, hypoxia improved. However, the results of determination of Na ~ (+) - K ~ (+) - ATPase activity in rat myocardial cells showed that the activity of this enzyme showed an upward trend. Compared with the saline group, there was no significant difference in enzyme activity, It is suggested that the recovery of Na ~ (+) pump in myocardial cell membrane is better than that of electrocardiogram, and the microthrombus is slowed down. It is emphasized that after the treatment of heparin, the cardioprotection should be strengthened at the beginning of ECG improvement.