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目的:研究来第四军医大学唐都医院传染科就诊的人类免疫缺陷病毒/艾滋病(Human immunodeficiency virus/Acquired immuno deficiency syndrome,HIV/AIDS)患者感染状况及抗病毒治疗效果。方法:采用前瞻性随访研究的方法,收集来我院就诊的HIV/AIDS患者的基本信息,并对其实验室检查结果、治疗方案及后续随访结果进行分析。结果:随访观察的43例HIV/AIDS患者治疗前平均基线CD4+T淋巴细胞计数为(330.74±176.35)cells/μL,CD8+T淋巴细胞计数为(1177.80±321.49)cells/μL,CD4+,CD8+T淋巴细胞比值为0.30±0.19;治疗一年后平均CD4+T淋巴细胞计数为(482.74±217.77)cells/μL,CD8+T淋巴细胞计数为(861.53±282.85)cells/μL,CD4+,CD8+T淋巴细胞比值为0.59±0.28。所有患者治疗一年后血浆HIV-RNA载量均达到检测限以下(<500copies/m L)。结论:规范的抗病毒治疗对于改善HIV/AIDS患者预后至关重要;基线CD4+T淋巴细胞计数越低,抗病毒治疗效果越差。
Objective: To study the status of infection and anti-virus treatment of human immunodeficiency virus / Acquired immuno-deficiency syndrome (HIV / AIDS) in infectious disease department of Tangdu Hospital of the Fourth Military Medical University. Methods: A prospective follow-up study was conducted to collect the basic information of HIV / AIDS patients who came to our hospital and analyze their laboratory test results, treatment options and follow-up results. Results: The mean baseline CD4 + T lymphocyte count and the number of CD8 + T lymphocytes in 43 HIV / AIDS patients were (330.74 ± 176.35) cells / μL and (1177.80 ± 321.49) cells / μL, CD4 + and CD8 + T lymphocyte ratio was 0.30 ± 0.19. After one year of treatment, the mean CD4 + T lymphocyte count was (482.74 ± 217.77) cells / μL, the number of CD8 + T lymphocytes was (861.53 ± 282.85) cells / μL, CD4 + + T lymphocyte ratio was 0.59 ± 0.28. Plasma HIV-RNA load reached below the limit of detection (<500 cops / mL) in all patients after one year of treatment. Conclusions: Standardized antiviral therapy is crucial for improving the prognosis of HIV / AIDS patients. The lower the baseline CD4 + T lymphocyte count, the poorer the antiviral treatment effect.