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蒽醌是一类广泛存在于药用植物中,具有多种药理活性的化合物,但其肝、肾毒性使它的成药性受到很大限制。为了确保含蒽醌类化合物中药临床应用的安全性和有效性,研究人员通过多种体内外实验对蒽醌类化合物的吸收和代谢进行了大量研究。目前针对此类研究的主要方法有在体肠灌流模型、Caco-2细胞模型、肠道菌群代谢、肝/肠微粒体代谢和血药浓度法等。文章就近5年来应用这些方法对蒽醌类化合物化学结构与转运关系、体内外的吸收代谢机制及其影响因素进行了综述。
Anthraquinone is a class of compounds widely present in medicinal plants with a variety of pharmacological activities, but its liver and nephrotoxicity has greatly restricted its medicinal properties. In order to ensure the safety and effectiveness of traditional Chinese medicine containing anthraquinone compounds, researchers have done a lot of research on the absorption and metabolism of anthraquinones through a variety of in vitro and in vivo experiments. At present, the main methods for such studies include in vivo intestinal perfusion model, Caco-2 cell model, intestinal flora metabolism, liver / intestinal microsome metabolism and plasma concentration method. In the recent five years, the article reviewed the relationship between the chemical structure and translocation of anthraquinones, the mechanism of absorption and metabolism in vitro and in vivo and the influencing factors.