1990年11月,大连市开发区某托儿所发生了一起以手、足、口部位出现皮疹、小疱为特点的疾病流行。根据临床表现、流行病学调查,确定为手足口病爆发,现报告如下:1 临床特点此次爆发中病例的临床特点为:(1)发病均较急,突然发病,大部分病例具发热,在38℃左右(仅2例达39℃以上),且有轻咳、流涕;(2)咽部均有充血,18例具口腔粘膜疱疹,14例舌缘糜烂。口腔粘膜疱疹约1～2mm,初为白疱,边缘充 In November 1990, a nursery school in Dalian Development Zone occurred with a disease epidemic characterized by rash and small blisters on the hands, feet and mouth. According to clinical manifestations, epidemiological survey, identified as hand-foot-mouth disease outbreak, are as follows: 1 Clinical features The clinical features of the outbreak cases are: (1) the incidence of acute, sudden onset, most cases with fever, At 38 ℃ (only 2 cases up to 39 ℃ above), and there is light cough, runny nose; (2) throat congestion, 18 cases of oral mucosal herpes, 14 cases of tongue edge erosion. Oral mucosal herpes about 1 ~ 2mm, early blisters, edge filling