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目的 比较卡托普利和阿司匹林联合与单独应用卡托普利对早期糖尿病肾病的治疗效果。方法 将６７ 例尿白蛋白排泄率（ Ｕ Ａ Ｅ Ｒ）２０ ～２００μｇ／ ｍｉｎ 的Ⅱ型糖尿病患者随机分为 Ｔ 组（３３ 例） 和 Ｃ 组（３４例） ，在降糖治疗的同时， Ｔ 组给予卡托普利和阿司匹林， Ｃ 组给予卡托普利，疗程为１２ 周，分别观察治疗前后两组 Ｕ Ａ Ｅ Ｒ 变化。结果 两组治疗后 Ｕ Ａ Ｅ Ｒ 水平均较治疗前明显下降（ Ｐ 分别为＜ ０ ．００５ ，＜ ０ ．０１） ，但 Ｔ组 Ｕ Ａ Ｅ Ｒ 下降程度明显大于 Ｃ 组（ Ｐ＜ ０ ．０５） 。结论 较之单独应用卡托普利，卡托普利和阿司匹林联合治疗早期糖尿病肾病，具有更显著的疗效。
Objective To compare the therapeutic effect of captopril and aspirin combined with captopril alone on early diabetic nephropathy. Methods Sixty-seven type Ⅱ diabetic patients with urinary albumin excretion rate (UA E R) of 20 ~ 200 μg / min were randomly divided into T group (33 cases) and C group (34 cases). At the same time of hypoglycemic treatment, T Group given captopril and aspirin, C group given captopril, treatment for 12 weeks, were observed before and after treatment UA E R changes. Results After treatment, the levels of UA E R in both groups were significantly lower than those before treatment (P <0 .005, <0.01), but the reduction of U A E R in T group was significantly greater than that in C group (P <0.05. ). Conclusion Compared with the single use of captopril, captopril and aspirin in the treatment of early diabetic nephropathy, with more significant effect.