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经皮腔内冠脉成形术（ＰＴＣＡ）后再狭窄的防治，包括采用补阳还五汤等方法已初见成效，实验表明ＰＴＣＡ术后兔胸主动脉的内膜厚度在用药和对照组间有显著差异（Ｐ＜０．０５）。采用原位引物标记法对术后７天的标本测得服药组与对照组血管内皮的ＰＤＧＦ受体ｍＲＮＡ表达有显著差异（Ｐ＜０．０５），此表明服药组的胸主动脉内皮ＰＤＧＦ受体的基因表达受到抑制，提示调节受创血管内皮ＰＤＧＦ受体的基因表达是补阳还五汤临床疗效的重要分子机制。
The prevention and treatment of restenosis after percutaneous transluminal coronary angioplasty (PTCA), including the use of Buyang Huanwu Decoction, has achieved initial success. Experiments have shown that the thickness of the intima of the thoracic aorta after PTCA is between the drug and the control group. There was a significant difference (P<0.05). The expression of PDGF receptor mRNA in the vascular endothelium was significantly different between the medication group and the control group by in situ primer labeling (P<0.05). This indicates that the PDGF in the thoracic aortic endothelium of the medication group is affected. The gene expression of the body is inhibited, suggesting that regulating the gene expression of PDGF receptor in the invasive vascular endothelium is an important molecular mechanism of the clinical efficacy of Buyang Huanwu Decoction.