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干扰素了(IFNs)是强有力的抗病毒,抗增生和免疫调制的蛋白质。随着干扰素的生物学和生物化学特性的研究进展。它们与人类疾病特别是癌症的关系的临床研究也得到加强。木文作者用不同剂量的PIF(芬兰红十字会生产的部分纯化的人白细胞干扰素)治疗3例癌症病人(病例1为转移性乳腺癌,病例2为转移性肾细胞癌,病例3为转移性结肠癌),以观察其血清中的抗人白细胞千扰素抗体.中和分析证明,用PIF 治疗前,病例1和病例2就有IFN—αA 抗体,而病例3没有;用PIF 治疗后.病例3产生了IFN—αA 抗体。病例1和病例2治疗前血清抗人白
Interferons (IFNs) are potent antiviral, antiproliferative and immunomodulatory proteins. With the development of research on the biological and biochemical characteristics of interferon. Their clinical research on the relationship with human diseases, especially cancer, has also been strengthened. The author uses three different doses of PIF (partially purified human interferon produced by the Finnish Red Cross Society) to treat 3 patients with cancer (case 1 is metastatic breast cancer, case 2 is metastatic renal cell carcinoma, case 3 is metastasis Colon cancer) to observe the serum anti-human leukocyte interferon antibody. Neutralization analysis demonstrated that before treatment with PIF, cases 1 and 2 had IFN-αA antibodies, and case 3 did not; after treatment with PIF Case 3 produced IFN-αA antibodies. Case 1 and Case 2 Pretreatment Serum Anti-human White