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用秋水仙素、氨基甲酸乙酯、丝裂霉素C和苯连续4或5天腹腔注射小鼠,观察骨髓多染红细胞微核出现率均值相应为5.625‰、4‰、8‰、7.2‰,与对照组1.5‰比较,有高度显著性差异(P<0.01)。外周血成熟红细胞微核出现率均值应为0.85‰、1.25‰、5.5‰、0.42‰,与对照组0.215‰比较,也有高度显著性差异(P<0.01)。结果表明:利用人、哺乳动物外周血成熟红细胞胞浆中所出现的微核作为对辐射损伤、药物及食品中毒、环境污染等研究中的一项生物学指标,具有一定的实践意义。
The mice were intraperitoneally injected with colchicine, ethyl carbamate, mitomycin C and benzene for 4 or 5 days. The average incidence of micronuclei in bone marrow multi-erythrocytes was 5.625, 4, 8 and 7.2, respectively. Compared with the control group 1.5, there was a highly significant difference (P<0.01). The mean frequency of micronuclei in peripheral blood mature red blood cells should be 0.85 ‰, 1.25 ‰, 5.5 ‰, and 0.42 ‰, compared with 0.215 对照 in the control group, there are also highly significant differences (P<0.01). The results showed that the use of micronuclei in the cytoplasm of mature red blood cells of humans and mammals as a biological indicator of radiation damage, drug and food poisoning, and environmental pollution has certain practical significance.