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目的 观察青霉素致白兔急性癫痫模型以及电针与手术对该模型的影响。方法 采用青霉素皮质注射制作新西兰白兔急性癫痫模型 ,并将其分为对照组 (用生理盐水皮质注射 )和癫痫组 ,癫痫组再分为非治疗组与治疗组 ,治疗组再分为电针组和手术组 ;观察发作情况、脑电图变化及治疗效果。结果 皮质注射后 ,对照组无癫痫发作 ,癫痫组 1 0 0 %出现临床癫痫发作表现 ,并在脑电图上表现为典型的尖波 ,棘波发放 ;非治疗组存活率为8 33% ,治疗组存活率为 80 77% (F =1 7 6 7,P <0 0 1 ) ;电针组存活率为 6 0 % ,手术组存活率为 93 75 % (F =4 5 1 3,P <0 0 5 )。结论 青霉素致白兔急性癫痫模型戊巴比妥钠的麻醉剂量为 (33 9± 1 3 2 8)mg/kg ,青霉素致痫剂量为 (0 4 4 6 1± 0 .2 5 4 9)万u/kg ,电针与手术在降低癫痫死亡率上有相当的意义 ,而手术治疗癫痫效果明显优于电针治疗。
Objective To observe the acute penile epilepsy induced by penicillin in rabbits and the effect of electroacupuncture and operation on the model. Methods The acute epilepsy model of New Zealand White rabbits was made by penicillin cortex injection and divided into control group (injected with normal saline cortex) and epilepsy group. Epilepsy group was divided into non-treatment group and treatment group. The treatment group was divided into EA Group and operation group; observation of seizures, EEG changes and treatment effect. Results After cortical injection, there was no seizure in the control group. The clinical seizures were found in 100% of the epilepsy patients, and showed typical spikes and spikes on the EEG. The survival rate of non-treatment group was 83.3% The survival rate of the treatment group was 80 77% (F = 176,7, P <0.01); the survival rate of the electro-acupuncture group was 60% and the survival rate of the operation group was 93 75% (F = 4 5 1 3, P <0 0 5). Conclusion The anesthetic dose of pentobarbital sodium in acute epilepsy model induced by penicillin was (33 9 ± 1 32 8) mg / kg in penicillin-induced rabbits, and the penicillin-induced seizure was (0 446 ± 0 25 49) u / kg, electroacupuncture and surgery in reducing the mortality rate of epilepsy has considerable significance, and surgical treatment of epilepsy was significantly better than electroacupuncture.