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三种主要的血红蛋白病是镰形细胞贫血,主要影响非洲人;β地中海贫血,影响地中海和亚洲人;α地中海贫血,严重流行于东南亚。逆转录酶和人类珠蛋白基因克隆的成功,使得探查异常基因成为可能。纯合α地中海贫血引起的胎儿水肿是研究α珠蛋白基因的理想标本,因为这
The three major hemoglobinopathies are sickle cell anemia that affects mainly Africans; beta thalassemia affects the Mediterranean and Asians; alpha thalassemia, which is endemic in Southeast Asia. The success of reverse transcriptase and human globin gene cloning made it possible to probe for abnormal genes. Fetal edema caused by homozygous α-thalassemia is an ideal specimen for studying the alpha-globin gene because