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Ca~(2+)与高血压发病密切相关,血管平滑肌(VSM)细胞内持续高Ca~(2+)水平是导致VSM张力增加、血压升高的根本原因。为了分析抗高血压因子(AHF)降压机理是否与抑制血管平滑肌Ca~(2+)内流有关,本实验观察AHF对大鼠动脉条Ca~(2+)内流及对大鼠离体血管舒张作用的影响。 一、Ca~(2+)内流实验 实验观察不同浓度AHF(10~(-7),10~(-6)和10~(-5)g/ml)对卒中易感型SHR(SH-Rsp,n=4)及WKY大鼠(n=5)主动脉(A)及肠系膜动脉(MA)条Ca~(2+)内流的影响。以~45Ca为
Ca 2+ is closely related to the pathogenesis of hypertension. Sustained high levels of Ca 2+ in vascular smooth muscle (VSM) cells are the underlying causes of increased VSM tension and elevated blood pressure. In order to analyze whether the antihypertensive mechanism of antihypertensive factor (AHF) is related to the inhibition of Ca ~ (2+) influx in vascular smooth muscle, we observed the effect of AHF on Ca ~ (2+) Effects of Vasodilatation. First, Ca ~ (2 +) influx experimentsThe effects of different concentrations of AHF (10 ~ (-7), 10 ~ (-6) and 10 ~ (-5) g / ml) on stroke-prone SHR Rsp, n = 4) and influx of Ca ~ (2+) in the aorta and mesenteric artery of WKY rats (n = 5). To ~ 45Ca for