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目的探讨血管内皮生长因子(vascular endthelial growth factor,VEGF)在分化型甲状腺癌中的表达及其与甲状腺癌临床病理特征之间的关系。方法采用免疫组化SP法检测57例分化型甲状腺癌、45例甲状腺良性病变和19例正常组织标本中的VEGF表达。结果VEGF在分化型甲状腺癌、甲状腺良性病变和正常甲状腺组织中的阳性表达率分别为86.9%、17.8%和10.5%,甲状腺癌中VEGF阳性表达与良性病变及正常组织相比差异均有统计学意义(P<0.05);VEGF强阳性表达在T3/T4、预后不良及复发组甲状腺癌中有更高的比例,差异有统计学意义(P<0.05),VEGF表达与预后指数呈正相关(r=0.320,P=0.015)。结论甲状腺组织中VEGF过表达可作为分化型甲状腺癌的一个辅助诊断和预后判断的指标,有助于预后不良的分化型甲状腺癌的筛选和鉴别。
Objective To investigate the expression of vascular endothelium growth factor (VEGF) in differentiated thyroid carcinoma and its relationship with the clinicopathological features of thyroid carcinoma. Methods Immunohistochemical SP method was used to detect VEGF expression in 57 cases of differentiated thyroid carcinoma, 45 cases of benign thyroid lesions and 19 cases of normal tissue specimens. Results The positive rates of VEGF expression in differentiated thyroid carcinoma, thyroid benign lesions and normal thyroid tissues were 86.9%, 17.8% and 10.5%, respectively. There were statistically significant differences in VEGF expression between thyroid carcinoma and benign lesions and normal thyroid tissues (P <0.05). The strong positive expression of VEGF in T3 / T4, poor prognosis and recurrence group had a higher proportion of thyroid cancer (P <0.05), VEGF expression was positively correlated with prognosis index (r = 0.320, P = 0.015). Conclusion The overexpression of VEGF in thyroid tissue can be used as an auxiliary diagnostic and prognostic indicator for differentiated thyroid carcinoma, which is helpful for the screening and identification of poorly differentiated thyroid carcinoma.