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26例应用口服降糖药血糖控制不理想的T2DM患者随机分为甘精胰岛素组(n=13)和预混胰岛素组(n=13)。原口服药不变,每晚10点注射甘精胰岛素。预混胰岛素组采用早、晚餐前30min皮下注射胰岛素,停服原有口服降糖药,若餐后血糖高,加用阿卡波糖片用量(150mg/d)。两组治疗目标为空腹血糖≤6.8mmol/L和餐后2h血糖≤10.0mmol/L。结果治疗后两组血糖均良好下降,但甘精组低血糖事件明显少于预混组。结论甘精胰岛素联合口服降糖药物可以良好地控制高血糖,且低血糖发生率低。
Twenty-six patients with T2DM who did not control their glycemic control with oral hypoglycemic agents were randomized into insulin glargine group (n = 13) and premixed insulin group (n = 13). The same oral medication unchanged, injection of glargine at 10 o’clock every night. Pre-mixed insulin group using early, subcutaneous insulin 30min before dinner, stop taking the original oral hypoglycemic agents, if postprandial blood glucose, add acarbose dosage (150mg / d). Two groups of treatment goals for fasting blood glucose ≤ 6.8mmol / L and postprandial blood glucose 2h ≤ 10.0mmol / L. Results After treatment, the blood glucose levels of both groups decreased well, but the hypoglycemic events in the Ganjing group were significantly less than those in the premixed group. Conclusion Glargine and oral hypoglycemic drugs can control hyperglycemia well, and the incidence of hypoglycemia is low.