国内外很多肿瘤研究都观察到旁观者效应诱导的细胞凋亡的存在,且细胞凋亡是旁观者效应重要的检测终点,对肿瘤治疗的疗效有着重要影响。旁观者效应能引起细胞死亡(包括凋亡)、细胞周期阻滞、基因表达、染色体畸变等生物学变化,有研究结果表明,多种信号转导途径参与了这个过程,包括氧化应激、缝隙连接介导的细胞间通讯。但其确切机制尚不明确。 Many oncology studies at home and abroad have observed the presence of apoptosis induced by bystander effect, and apoptosis is an important end point of bystander effect, which has an important impact on the curative effect of tumor therapy. Bystander effect can cause cell death (including apoptosis), cell cycle arrest, gene expression, chromosome aberrations and other biological changes, studies have shown that a variety of signal transduction pathways involved in this process, including oxidative stress, cracks Connection mediated cell-to-cell communication. But the exact mechanism is not yet clear.