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目的:探索黄酮醋酸类化合物中间体的合成方法。方法:通过酰基化、Fries重排、氯甲基化合成2-羟基-3-氯甲基-5-甲基苯乙酮,并应用(HCHO)n/HCI系统进行氯甲基化,获得了满意的收率(90.4%)。结果:采用新方法合成了未见文献报道的新化合物2-羟基-3-氯甲基-5-甲基苯乙酮。结论:该方法具有反应时间短、操作简便、收率好等优点。
Objective: To explore the synthesis of flavonoids acetic acid intermediates. Methods: 2-Hydroxy-3-chloromethyl-5-methylacetophenone was synthesized by acylation, Fries rearrangement and chloromethylation, and chloromethylated using (HCHO) n / HCl system to obtain Satisfactory yield (90.4%). Results: The novel compound 2-hydroxy-3-chloromethyl-5-methylacetophenone was synthesized by a novel method. Conclusion: The method has the advantages of short reaction time, easy operation and good yield.