冠心病(CHD)是严重危害人类健康的心脑血管疾病。引起CHD的危险因素很多,其中血脂异常最为重要。一系列临床试验证实冠心病的预防可从降低总胆固醇、低密度脂蛋白胆固醇(LDL-C)、三酰甘油和升高高密度脂蛋白胆固醇(HDL-C)入手。胆汁酸是胆固醇分解的终产物。血清中胆汁酸含量的高低能够反映人体胆固醇代谢能力的高低,因此研究改变胆汁酸在血清中含量的方法对于治疗CHD具有重 Coronary heart disease (CHD) is a serious cardiovascular disease affecting human health. The risk of CHD caused by many factors, including dyslipidemia is the most important. A series of clinical trials confirmed that prevention of coronary heart disease can be started by lowering total cholesterol, low density lipoprotein cholesterol (LDL-C), triglyceride and increasing high density lipoprotein cholesterol (HDL-C). Bile acids are the end products of cholesterol breakdown. Serum bile acid levels reflect the level of human cholesterol metabolism, therefore, to study the method of changing the content of bile acids in the serum for the treatment of CHD has a heavy