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目的 探讨阿霉素磁液经消化道给药后 ,联合外磁场对鼠种植性胃肿瘤的靶向治疗作用机制。方法 利用Walker- 2 5 6瘤细胞制作鼠种植性胃肿瘤模型 ,并分成阿霉素磁液联合外磁场的靶向组 ,单纯阿霉素治疗的非靶向组及空白对照组。观察动物的一般状况 ,肿瘤生长率 ,病理组织学改变及动物生存时间等变化。结果 与空白对照组比较 ,靶向组动物肿瘤生长明显缓慢 ,瘤重及瘤体积抑制率分别为 78.0 8%和 82 .5 2 % (χ2 =2 7.96 ,P <0 .0 1) ,动物生存时间明显延长 ,延长率达2 86 .38% (χ2 =19.5 4,P <0 .0 1) ,并出现明显病理组织学改变。结论 磁场联合阿霉素磁液的靶向治疗 ,具有明显协同的抑制鼠种植性胃肿瘤生长的作用 ,为进一步临床应用提供实验依据
Objective To investigate the mechanism of targeted treatment of murine gastric cancer with external magnetic field after doxorubicin magnetic fluid administration through the digestive tract. METHODS: A mouse gastric tumor model was established using Walker-2 5 6 tumor cells and divided into a targeting group of adriamycin magnetic fluid combined with an external magnetic field, a non-targeting group of adriamycin alone and a blank control group. Observe the general condition of the animals, tumor growth rate, histopathological changes, and animal survival time. Results Compared with the blank control group, the growth of tumors in the target group was significantly slower, and the tumor weight and tumor volume inhibition rates were 78.0 8% and 82.52% (χ2 = 2 7.96, P < 0.01), respectively. Animal survival The time was significantly prolonged, the prolongation rate was 286.38% (χ2=19.54, P<0.01), and obvious histopathological changes appeared. Conclusion The magnetic field combined with doxorubicin magnetic fluid targeted therapy has obvious synergistic effect on inhibiting the growth of implanted gastric tumors in rats, providing experimental basis for further clinical application.