单克隆抗体(McAb)的发展,给临床医生和研究人员提供了一种有力的探测器。这种经过实践可能用于临床的新技术,对人类生物学将产生巨大影响。由于皮肤易于取样,且具有许多分化不同型的细胞和细胞产物,皮肤病学可能是受影响最深的学科之一。 Kohler等研究抗体合成时,用鼠的正常B细胞和恶性骨髓瘤细胞杂交融合,被骨髓瘤鲴胞的DNA结合可分泌大量的特殊抗体并增殖为不断扩大的克隆。这些永存的抗 The development of monoclonal antibodies (McAb) provides clinicians and researchers with a powerful detector. This new technology, which may be clinically used in practice, will have a huge impact on human biology. Dermatology may be one of the most affected disciplines, because the skin is easy to sample and has many differentiated cells and cellular products. When Kohler et al. Studied antibody synthesis, the murine normal B cells and malignant myeloma cells were hybridized and fused. DNA binding by myeloma cells secreted large amounts of specific antibodies and proliferated into ever-expanding clones. These eternal resistance