论文部分内容阅读
目的探讨血清胱抑素C(Cyst C)在老年人造影剂肾病(CIN)中的评估作用。方法 126例接受造影剂检查的老年患者,根据血肌酐(Scr)水平分为CIN组和非CIN组。比较两组临床资料及基线和应用造影剂后第1、3、7天Cyst C、Scr水平。结果 126例老年患者有12例(9.5%)发生CIN,均为非少尿型急性肾衰竭。CIN组糖尿病、心力衰竭、高血压、冠心病或周围动脉粥样硬化症的患病率(分别为75.0%、33.3%、91.7%、100.0%)明显高于非CIN组(分别为40.4%、10.5%、68.4%、89.5%),差异有统计学意义(P<0.05)。在CIN组中,Cyst C水平达到峰值的时间为应用造影剂后第1天,而Scr为应用造影剂后第3天。在非CIN组中,在应用造影剂后第3天,Cyst C已降至基线水平,并稳定于基线水平;而Scr有逐渐增加的趋势,但与基线水平相比,差异无统计学意义(P>0.05)。结论血清Cyst C和Scr均能对应用造影剂后肾功能做有效评估,但与Scr相比,Cyst C能更敏感、准确地反映老年人肾功能的变化情况。
Objective To evaluate the evaluation of serum cystatin C in contrast-induced nephropathy (CIN) in the elderly. Methods 126 elderly patients undergoing contrast medium were divided into CIN group and non-CIN group according to the level of serum creatinine (Scr). Cyst C and Scr levels were compared between the two groups on the 1st, 3rd, 7th day after treatment with baseline and contrast agent. Results CIN occurred in 126 of 126 elderly patients (9.5%), all of which were non-oliguric acute renal failure. The prevalence of diabetes, heart failure, hypertension, coronary heart disease or peripheral atherosclerosis in CIN group (75.0%, 33.3%, 91.7%, 100.0%, respectively) was significantly higher than that in non-CIN group (40.4% 10.5%, 68.4%, 89.5%), the difference was statistically significant (P <0.05). In the CIN group, Cyst C levels peaked on day 1 after contrast media administration and Scr on day 3 after contrast media administration. In non-CIN group, Cyst C had dropped to baseline level and stabilized at baseline on the third day after administration of contrast medium, whereas Scr showed a gradual increase but no significant difference from baseline P> 0.05). Conclusions Serum Cyst C and Scr can all be used to evaluate the renal function after contrast medium. However, compared with Scr, Cyst C can reflect the change of renal function more sensitively and accurately.