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目的:分析糖皮质激素联合免疫球蛋白治疗需要机械通气的吉兰巴雷综合征的临床疗效。方法:回顾性分析2008年1月至2016年7月西安市六家医院收治的采用机械通气的吉兰巴雷综合征患者的临床资料,并对其进行随访,比较单用免疫球蛋白与糖皮质激素联合免疫球蛋白的疗效差异。结果:两组在出院时及出院后6个月的总有效率(MRC及HFGS的改善率)、死亡率、机械通气时间、住院时间、在ICU住院时间、出院时及出院后6个月的MRC总得分和HFGS得分以及并发症发生率比较差异均无统计学意义(P>0.05)。结论:对于机械通气的吉兰巴雷综合征患者,在使用免疫球蛋白的基础上增加糖皮质激素的使用,对其短期(出院时)及较长期(出院后6个月)的临床疗效和安全性均无显著影响。
OBJECTIVE: To analyze the clinical efficacy of glucocorticoid combined with immunoglobulin in the treatment of Guillain-Barre syndrome requiring mechanical ventilation. Methods: The clinical data of patients with Guillain-Barre syndrome treated by mechanical ventilation in six hospitals in Xi’an from January 2008 to July 2016 were retrospectively analyzed and followed up. The levels of immunoglobulin alone and sugar Efficacy of corticosteroid combined with immunoglobulin. Results: The total effective rate (improvement rate of MRC and HFGS), mortality rate, duration of mechanical ventilation, length of stay, time of hospital stay, discharge at hospital and 6 months after discharge at 6 months after discharge and 6 months after discharge MRC total score and HFGS scores, as well as the incidence of complications was no significant difference (P> 0.05). Conclusions: The use of glucocorticoids based on the use of immunoglobulins in patients with mechanically-induced Guillain-Barre syndrome increases the clinical efficacy of short-term (discharge) and longer-term (6 months after discharge) and No significant safety impact.