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在一10名研究者参与的多中心,安慰剂对照,随机双盲的试验中,经内窥镜诊断为胃溃疡的129例病人(溃疡大小均在3～30mm之间),随机分成3组,分别接受enprostil 75μg(A组)、35μg(B组)或安慰剂(C组),均按每天2次给药。于试验的第2、4和6周重新进行内窥镜评价。试验2周后,所有治疗组的溃疡愈合率近似;4周后,enprostil治疗组开始呈示出一定的疗效,A、B、C各组的愈合率依次为52、54和35%;6周后,疗效出现较大的不
In a multicenter, placebo-controlled, randomized, double-blind trial involving 10 investigators, 129 patients with endoscopic gastric ulceration (ulcer size between 3 and 30 mm) were randomly assigned to 3 groups , Receiving either enprostil 75 μg (group A), 35 μg (group B) or placebo (group C), were given twice daily. Endoscopic evaluations were repeated on weeks 2, 4 and 6 of the trial. After 2 weeks of treatment, ulcer healing rate was similar in all treatment groups. After 4 weeks, the enprostil treatment group started to show some curative effect, and the healing rates of groups A, B and C were 52, 54 and 35% respectively. After 6 weeks , The larger the effect does not appear