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用图象分析法对２０７例人正常肝、慢性肝炎、肝硬化、肝细胞不典型增生（ＬＣＤ）和肝细胞肝癌（ＨＣＣ）中的细胞ＤＮＡ指数（ＤＩ）、增殖指数（ＰＩ）、核面积（ＮＡ）、二倍体细胞比率（２ＣＲ）和超五倍体细胞百分比（５ＣＥＲ）等项参数进行定量测定；同时进行核仁组织区（ＡｇＮＯＲｓ）计数及其与ＤＮＡ含量相关关系研究。结果显示：人肝癌的发生符合肿瘤发生多阶段理论。癌前病变ＬＣＤ其各项指标均显著增加，其中异倍体ＬＣＤ各项指标与ＨＣＣ＋分接近。因而提出异倍体ＬＣＤ作为病变进入演进期的标志，为肝癌发生的终未阶段，也是癌变的关键。
Image analysis of cellular DNA index (DI), proliferation index (PI), nuclear area in 207 cases of human normal liver, chronic hepatitis, cirrhosis, hepatocellular atypical hyperplasia (LCD), and hepatocellular carcinoma (HCC) The parameters such as (NA), diploid cell ratio (2CR) and super quintile cell percentage (5CER) were quantitatively determined; at the same time, the counts of AgNORs and their correlation with DNA content were studied. The results show that the occurrence of human liver cancer is in line with the multistage theory of tumorigenesis. The indicators of precancerous lesions were significantly increased, and the aneuploidy LCDs were close to the HCC score. Therefore, it is proposed that the aneuploid LCD is the sign of the progression of the lesion into the evolutionary stage. It is the final stage of the occurrence of liver cancer and is also the key to canceration.