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实验结果表明在小鼠的两种行为实验中,训练后立即腹腔注射纳洛酮0.3 mg/kg能增强记忆的保持;注射甲啡肽0.5～2.0μg/kg则减弱记忆的保持。纳洛酮的效应可被同时注射吗啡或甲啡肽所阻断。切断支配小鼠肾上腺的神经后,同上剂量纳洛酮对记忆保持不再产生影响。此结果提示内源性甲啡肽和肾上腺髓质内分泌可能参与记忆巩固的调制。
Experimental results showed that intraperitoneal injection of naloxone 0.3 mg / kg intraperitoneally during 2 behavioral experiments in mice enhanced memory retention; 0.5 ~ 2.0 μg / kg injection of morphine attenuated the retention of memory. The effect of naloxone can be blocked by the simultaneous injection of morphine or methamide. After cutting off the nerves that dominate the mouse adrenal glands, the same dose of naloxone no longer affects memory retention. This result suggests that endogenous endorphin and adrenal medulla may be involved in memory consolidation modulation.