胃肠道间质瘤(gastrointestinal stromal tumor,GIST)是发生于胃肠道最常见的间叶源性肿瘤,其免疫表型表达c-Kit蛋白(CD117),遗传学上有c-Kit基因突变,具有潜在恶性倾向的肿瘤[1]。自1983年首次提出GIST的慨念以来.对该疾病的认知随着临床病理技术和分子生物技术的发展而逐渐成熟。由于GIST疾病的复杂性,仍存在众多的未认知区域。本文就GIST目前的研究进展作一综述。 Gastrointestinal stromal tumor (GIST), the most common mesenchymal tumor that occurs in the gastrointestinal tract, has an immunophenotype that expresses c-Kit protein (CD117) and genetically has a c-Kit mutation , A potentially malignant tumor [1]. Since the idea of ​​GIST was first proposed in 1983, the awareness of the disease has matured with the development of clinical pathology and molecular biotechnology. Due to the complexity of GIST disease, there are still many unrecognized areas. This article reviews the current research progress of GIST.