应用国产及西德产吡喹酮治疗血吸虫病139例,观察副作用时采用双盲法,结果显示吡喹酮对症状方面的副作用并不明显,但治后出现2例房颤,并有6.5%的患者尿检轻度异常,可能与药物有关。考核疗效时采用空白对照,治后5～7月粪孵阴转率国产和德产吡喹酮分别为98.5%和98.4%,但未治患者亦有34.3%自然阴转。讨论中强调了对照研究的重要性。 Application of domestic and West Germany praziquantel treatment of schistosomiasis in 139 cases, the side effects observed by double-blind method, the results show that the side effects of praziquantel on the symptoms is not obvious, but after the treatment of two cases of atrial fibrillation, and 6.5% Patients with urinalysis mild abnormalities, may be related to drugs. Blank control was used to evaluate curative effect. After the treatment, the rates of domestic and poultry hatching negative conversion from May to July were 98.5% and 98.4%, respectively, but 34.3% of the untreated patients also had natural overcast. The discussion highlighted the importance of the control study.