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目的：研究病毒性肝炎患者透明质酸（ＨＡ）的含量、变化规律及临床意义。方法：采用放射免疫分析测定法（ＲＩＡ）对２７２例病毒性肝炎患者进行血清透明质酸的测定。结果：结果表明各临床类型肝炎的ＨＡ均高于正常人，升高的特点为急性肝炎（１３６．４２±１０１．２８ｎｇ／ｍｌ）小于慢性活动性肝炎（３６４．５６±２９６．４１ｎｇ／ｍｌ）小于肝炎后肝硬化（９９８．７２±３６３．４３ｎｇ／ｍｌ）。动态观察肝炎患者ＨＡ浓度的变化，发现急性肝炎ＨＡ浓度随病情恢复而降低，慢性活动性肝炎及肝硬化则恒于较高值。结论：认为ＨＡ可作为诊断肝纤维化的指标之一，对肝病的诊断，鉴别诊断与判断预后有一定的意义
Objective: To study the content, change and clinical significance of hyaluronic acid (HA) in patients with viral hepatitis. Methods: Serum hyaluronic acid was determined in 272 patients with viral hepatitis by radioimmunoassay (RIA). Results: The results showed that the HA of each clinical type of hepatitis was higher than that of normal people. The characteristics of elevated hepatitis were as follows: acute hepatitis (136.42 ± 101.28ng / ml) less than chronic active hepatitis (364.56 ± 296.41ng / ml) Less than cirrhosis after hepatitis (998.72 ± 363.43ng / ml). Dynamic observation of hepatitis patients HA concentration changes, found that the concentration of HA in acute hepatitis decreased with the recovery of the disease, chronic active hepatitis and cirrhosis are constant at higher values. Conclusion: It is suggested that HA can be used as one of the indexes to diagnose liver fibrosis, which has certain significance for the diagnosis, differential diagnosis and prognosis of liver disease