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目的探讨胃食管反流病(gastroesophagealrefluxdisease,GERD)与胃酸胆汁联合反流的关系。方法2002-09～2004-09河南大学淮河医院及新乡医学院第二附属医院住院及门诊GERD患者82例,其中非糜烂性反流病(nonerosiverefluxdisease,NERD)22例,反流性食管炎(refluxesophagitis,RE)31例,Barrett食管(Barrett esophagus,BE)29例及健康对照组20例。应用便携式24hpH监测仪和胆汁反流监测仪对三组患者及对照组进行24h食管内pH和胆汁动态联合监测。结果RE、BE患者胃酸和胆汁联合反流比NERD患者和对照组更加频繁。结论胃酸和胆汁的联合反流在RE和BE的发病机制中起着更加重要的作用,同步监测食管pH值及胆汁变化对RE、BE的诊断和治疗具有重要的意义。
Objective To investigate the relationship between gastroesophageal reflux disease (GERD) and gastric acid-bile reflux. Methods A total of 82 hospitalized and outpatient GERD patients from Huaihe Hospital of Henan University and the Second Affiliated Hospital of Xinxiang Medical College from September 2002 to June 2004 were enrolled. Among them, 22 cases were nonerosivereflux disease (NERD), 22 cases were reflux esophagitis , RE), 29 cases of Barrett’s esophagus (BE) and 20 cases of healthy control group. The 24-hour monitoring of esophageal pH and bile dynamics was performed on the three groups of patients and the control group using a portable 24hpH monitor and a bile-reflux monitor. Results RE, BE patients with gastric acid and bile reflux more frequently than NERD patients and controls. Conclusions Combined reflux of gastric acid and bile plays a more important role in the pathogenesis of RE and BE. Simultaneous monitoring of esophageal pH and bile changes is of great significance for the diagnosis and treatment of RE and BE.