目的：探讨慢性阻塞性肺病（ＣＯＰＤ）病人进行机械通气治疗对短期预后的影响因素。方法：以回顾性分析的方式根据能否成功脱机把４３例ＣＯＰＤ急性加重而进行通气治疗的病人分成生存和死亡两组，对插管前２４小时的临床和实验室资料等进行比较，并对其与能否成功脱机的关系进行多因素ｌｏｇｉｓｔｉｃ逐步回归分析。结果：感染和合并其他系统疾病是死亡的危险因素（比值比分别为６３９２、４４９１，Ｐ分别为００１２、００１９），呼吸急性生理学评分是保护性因素（比值比为０８６９，Ｐ＝００２９）。结论：ＣＯＰＤ患者插管前的临床资料对短期预后有一定预测性 Objective: To investigate the influencing factors of short-term prognosis of patients with chronic obstructive pulmonary disease (COPD) treated with mechanical ventilation. Methods: According to the retrospective analysis, 43 patients with acute exacerbation of COPD were divided into survival and death according to the ability to go offline successfully. Clinical and laboratory data of 24 hours before intubation were compared and analyzed. Multivariate logistic stepwise regression analysis was performed on the relationship with the success of offline. Results: Infection and other systemic diseases were the risk factors for death (odds ratios were 6392, 4491, P = 012, 0019, respectively). Acute respiratory physiology score was a protective factor (odds ratio 0869, P = 0029). Conclusion: The clinical data of patients with COPD before intubation may have certain predictive value for short-term prognosis