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临床上应用(131)~Ⅰ作用于甲状腺组织使其萎缩、以达到治疗疾病目的。口服(131)~Ⅰ后,甲状腺局部组织剂量较大,甲状腺以外脏器也受到一定剂量照射,口服3.7×10~7贝可(131)~Ⅰ后,全身组织平均受照剂量一般为0.002～0.009戈瑞,生殖腺为0.005～0.02戈瑞。因此,研究甲尤患者口服(131)~Ⅰ治疗后机体效应,探讨染色体畸变和微核的变化,积累资料,有助于进一步认识(131)~Ⅰ对人体的危害。研究(131)~Ⅰ的放射毒理作用机理是很有意义的一项工作。
Clinical application (131) ~ Ⅰ role in the thyroid tissue to shrink, in order to achieve the purpose of treatment of disease. After oral administration (131) ~ Ⅰ, the thyroid gland has a large local tissue dose and organs outside the thyroid gland are also exposed to a certain dose. After oral administration of 3.7 × 10 ~ 7 becquerels (131) ~ Ⅰ, the average dose of the whole body tissue is generally 0.002 ~ 0.009 Gray, gonads 0.005 to 0.02 Gray. Therefore, to study the body effect after oral (131) ~ Ⅰ treatment in Jia You patients and to explore the changes of chromosomal aberrations and micronuclei and to accumulate data will help to further understand the harm of (131) ~ Ⅰ to the human body. It is of great significance to study the mechanism of radiation toxicology of (131) ~ Ⅰ.