自从1972年Oppenheimer等首次证实大鼠垂体、肝和肾细胞核中存在高亲和力、有限结合容量的特异性T_3受体以来,已在多种动物和人的组织细胞中发现了类似的核T_3受体。十余年的研究证明、甲状腺激素对靶细胞的作用主要是通过T_3受体产生的。T_3与特异性核T_3受体结合,是甲状腺激素产生生物效应的始动环节;由此调节基因表达,影响转录过程,直接或间接地促进各种mRNA的形成,进而影响蛋白质或酶的合成,产生 Since Oppenheimer et al. First demonstrated in 1972 that there is a high affinity, limited binding capacity specific T_3 receptor in rat pituitary, liver and kidney nuclei, a similar nuclear T_3 receptor has been found in many animal and human tissue cells . More than ten years of research have shown that the role of thyroid hormones on target cells is mainly generated by the T_3 receptor. T_3 and specific nuclear T_3 receptor binding, is the thyroid hormone biological effects of the first move; thus regulating gene expression, affecting the transcription process, directly or indirectly, to promote the formation of a variety of mRNA, thereby affecting the protein or enzyme synthesis, produce