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目的探讨急性胰腺炎患者严重程度与血清Hcy、hs-CRP、PCT和D-D水平相关性的临床研究。方法测定113例急性胰腺炎(AP)患者,其中76例轻中症AP(MAP)和37例重症AP(SAP)患者以及60例正常对照组血清Hcy、hs-CRP、PCT和D-D水平,并进行了对比性研究。结果 113例AP患者Hcy、hs-CRP、PCT和D-D水平高于60例正常对照组,差异有统计学意义(P<0.01),113例AP患者血清Hcy、hs-CRP、PCT和D-D的阳性率分别为74.34%、94.69%、92.04%、65.49%。113例AP患者单一血清Hcy、hs-CRP、PCT和D-D单一指标的敏感度分别为66.37%、69.03%、61.95%、60.18%,2个指标联合检测的敏感度为68.14%~72.57%,3个指标联合检测的敏感度为73.45%~74.34%,4个指标联合检测的敏感度为82.30%。结论 AP患者血清Hcy、hs-CRP、PCT和D-D水平以及阳性率和敏感度随疾病的严重程度而增高,这为多指标联合检测AP患者的早期诊断和积极治疗提供了有价值的指标。
Objective To investigate the relationship between the severity of acute pancreatitis and serum Hcy, hs-CRP, PCT and D-D levels. Methods Serum levels of Hcy, hs-CRP, PCT and DD were measured in 113 patients with acute pancreatitis (AP) and 76 patients with mild-stroke AP (MAP), 37 with severe SAP (SAP) and 60 normal controls A comparative study was conducted. Results The levels of Hcy, hs-CRP, PCT and DD in 113 AP patients were higher than those in 60 normal controls (P <0.01). The positive rates of serum Hcy, hs-CRP, PCT and DD in 113 AP patients Rates were 74.34%, 94.69%, 92.04%, 65.49% respectively. The sensitivities of single serum Hcy, hs-CRP, PCT and DD were 113.3%, 69.03%, 61.95% and 60.18%, respectively. The sensitivities of the two indexes were 68.14% -72.57%, 3 The sensitivities of the joint detection of the three indicators were 73.45% ~ 74.34%, the sensitivity of the four indicators combined detection was 82.30%. Conclusions The serum Hcy, hs-CRP, PCT and D-D levels and the positive rate and sensitivity of patients with AP are increased with the severity of the disease. This provides a valuable index for the early diagnosis and active treatment of AP in patients with AP.